Prescription only · clinician reviewed
MOTS-c — 2 mg/mL
A mitochondrial peptide studied for how the body uses energy. Ready to use.
Member pricing via Renovatti Wellness
Choose your plan
- One charge for this supply
- Clinician review and care-team messaging included
- Pay once for this supply. No automatic renewal — start a new consult if you want more later.
- This is not a subscription. There is nothing to cancel.
- One charge for this supply
- Clinician review and care-team messaging included
- Pay once for this supply. No automatic renewal — start a new consult if you want more later.
- This is not a subscription. There is nothing to cancel.
Free eligibility check · $0 today · You are charged only if a clinician prescribes
Shipping and clinician visit added at checkout.
Choosing a plan starts an intake, not an order. A licensed clinician reviews it and decides whether to prescribe — they may decline, and you are not charged unless they approve.
MOTS-c — 2 mg/mL
A mitochondrial peptide studied for how the body uses energy. Ready to use.
- Metabolic efficiency
- Physical performance
- Cellular longevity
Why people ask about it
What this is for
Metabolic efficiency
In mouse studies, MOTS-c improved how muscle took up and used glucose.
Physical performance
Natural MOTS-c rises with exercise in people, and in older mice treatment was linked to better running capacity.
Cellular longevity
MOTS-c levels fall with age in some studies, which is why it is studied in aging research. Whether it changes aging in people is unknown.
Individual results vary. Your clinician decides whether it is right for you.
Before you start
What to know about MOTS-c
MOTS-c is a small peptide made from instructions in your mitochondria's own DNA. It is studied for how muscle handles glucose and responds to exercise. A licensed clinician reviews your intake by message and decides whether it fits you.
- 01
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA.
- 02
In cells it activates AMPK, the same energy sensor exercise switches on.
- 03
Mouse studies showed better insulin sensitivity and physical capacity. Human trials are limited.
- 04
Ready to use at 2 mg/mL, in a 5 mL or 10 mL vial.
- 05
Supplied as a compounded medication, which means it is not FDA-approved.
Who this tends to fit
- You are interested in metabolic health and exercise capacity
- You are active and want clinician-guided support
- You want a ready-to-use vial
- You want a clinician to review it first
Fitting the description does not mean you will be prescribed this. A clinician decides after reviewing your intake.
Supplied as a compounded medication, so it is not FDA-approved and the FDA has not reviewed it for safety, effectiveness, or quality. The research on MOTS-c is mostly in cells and mice. Human studies mostly measure natural MOTS-c levels in the blood, and controlled trials of injected MOTS-c are limited. It is not a treatment for diabetes, obesity, or any other disease.
The science
The science of MOTS-c
Tap a card to see the research behind each pathway.
How care works
What clinician oversight means here
Licensed clinicians, real review, and support after you start.
A licensed clinician decides
Your intake is reviewed by a clinician licensed in your state. They choose the treatment and the dose, and they can decline. Insert MD does not make that call.
Dispensed by a licensed pharmacy
Nothing ships without a prescription. Your order is prepared and sent by a licensed pharmacy, not packed by us.
Reviewed again at follow-up
Continuing is a decision, not a default. Your clinician reassesses whether the treatment still fits before you carry on.
Compounded is not FDA-approved
Several treatments here are compounded. The FDA does not review compounded medications for safety, effectiveness, or quality, and we say so on every page where it applies.
How it works
Three steps, no charge to find out
Check eligibility
A quick questionnaire — takes about 2 minutes. No charge to see if you qualify.
Provider review
A licensed clinician reviews your intake and approves an appropriate plan.
Delivered to you
Your treatment ships directly to your door, with care-team support.
Precise, consistent dosing
Your prescription is prepared by a licensed pharmacy and reviewed by a clinician licensed in your state. Nothing ships until they approve.
- Compounded by a licensed pharmacy
- Dose set by a licensed clinician
- Ships ready to use — no home mixing
Good to know
MOTS-c is encoded in mitochondrial DNA and released into the blood. In cells under metabolic stress it activates AMPK, an energy sensor, and moves into the nucleus to switch on stress-response genes. In mice it improved insulin sensitivity on a high-fat diet and physical capacity in older animals. Those are animal results.
Supplied as a compounded medication, so it is not FDA-approved and the FDA has not reviewed it for safety, effectiveness, or quality. The research on MOTS-c is mostly in cells and mice. Human studies mostly measure natural MOTS-c levels in the blood, and controlled trials of injected MOTS-c are limited. It is not a treatment for diabetes, obesity, or any other disease.
Both are 2 mg/mL. The 5 mL vial is priced as about a 30-day supply at a typical dose and the 10 mL vial as about 60 days. Your clinician's dose decides how long either lasts.
Yes. It ships as a ready-to-use liquid, so there is nothing to mix.
No. It is not a GLP-1 and is not approved for weight loss. If weight loss is your main goal, ask about a weight-loss program instead.
References
Scientific sources
The primary papers, for readers who want to go deeper.
- 1.Kim KH, Son JM, Benayoun BA, Lee C. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metab. 2018;28(3):516-24.
- 2.Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-54.
- 3.Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.
Plain language
Terms you might hear
- Peptide
- A short chain of amino acids. Most act as signals between cells.
- Mitochondria
- Structures inside cells that turn nutrients and oxygen into usable energy.
- Mitochondrial DNA
- A small set of genes inside mitochondria, separate from the DNA in the cell nucleus. MOTS-c is encoded there.
- AMPK
- An enzyme that senses when a cell is low on energy and switches on processes that make more. Exercise activates it.
- Insulin sensitivity
- How well the body's cells respond to insulin and take up glucose from the blood.
- Compounded
- Prepared for an individual patient by a licensed pharmacy. Compounded medications are not FDA-approved.
Ready when you are
See if MOTS-c is right for you
A licensed clinician reviews your intake and decides. You are not charged unless they approve.
MOTS-c — 2 mg/mL
From $149.00 · $0 today